to their size & movements are measured by tracking and recording scattered light from particles in videos


AS DISCOVERED BY EINSTEIN et al, for nanoparticles undergoing Brownian motion

their movements are related to their size (smaller sizes move more vigorously). MANTA accurately measures the motion of particles in liquids over time by tracking scattered light from each particle.

Since these measurements are made individually on

all particles, and the tested volume is well known, particle size distribution is accurately determined.

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Manta enables in-situ measurements

of particle size distribution (PSD) with its elegant and absolute method that does not require calibration standards or knowledge of particle material properties such as refractive index. Multispectral optical methods and software enable MANTA to make accurate measurements of PSD across a wide range of nanoparticle sizes simultaneously which enables unmatched visualization and characterization of particle kinetic processes. In addition, with this multispectral method, customers can enumerate different constituents in the same sample under the same size distribution.

Under The Hood

The system characterizes nanoparticles by analyzing their movements in Brownian motion and larger, micron-sized particles by analyzing their settling motion (driven by gravity). The system leverages innovative illumination and detection techniques that enable video recording of scattered light from wide-ranging sizes of individual particles simultaneously.

A key advancement of this system

is its ability to work with the very large dynamic range of scattered light intensity produced by differently-sized nanoparticles coexisting in a polydisperse sample. As can be seen in the graph, the range of scattering cross-section (directly related to scattering intensity) spans eight orders of magnitude across the nanoparticle size range of only two orders of magnitude.


Test results from other light scattering techniques

typically have significant artifacts and uncertainties as a result of this massively disproportionate scattered light intensity. The issue being, very high intensities of scattered light from larger particles overwhelm the typical detection systems and obscure the analysis of other particles coexisting in the sample.

MANTA’s breakthrough technology

for addressing this huge range of scattered light intensity includes

A plurality

of lasers

A detection system

that can simultaneously, and individually,
track the light scattered from particles

Software to control the system

and analyze the light scattered from particles
on a particle-by-particle basis

With these innovations, MANTA divides the previously unmanageable dynamic range of scattered light intensity from sub-micron particles into discrete and manageable segments. With MANTA customers are able, for the first time, to visualize nanoparticles and measure particle size distribution for nanoparticle samples containing a wide range of particle sizes. This capability also provides additional benefits, such as measuring particle kinetic processes.

The ViewSizer’s® proprietary multispectral illumination and detection enables unique capabilities in the field of fluorescent particle analysis. Now for the first time, customers can enumerate different constituents in the same sample under the same size distribution. The overlapped PSDs in the graph show how the ViewSizer® can determine the concentration of each of the three constituents and their percentages of the total mixture. Imagine the possibilities – it’s like flow cytometry for nanoparticles.

Manta can visualize a Wide Range

MANTA can visualize a wide range of nanoparticle sizes simultaneously. This unique capability, enables various benefits including accurate measurement of nanoparticle size distribution and nanoparticle kinetic processes with one easy-to-perform test on particles in liquids.

As the saying goes “you can’t manage what you can’t measure.”

Why is This Important?

In most applications it is important to produce nanoparticles within a certain range of sizes. If the measurement technique is not able to provide accurate particle size distributions, you cannot manage your processes to make more of the desired particles and less of the out of spec particles. Similarly it’s hard to optimize process yields if you cannot measure particle concentrations. And if you want to know about particle kinetic processes you’ll need accurate PSD measurements and / or particle visualization over time. These needs are important across the full range of nanoparticle commercialization efforts – from R&D to manufacturing.